Six medium-range ballistic missiles were launched on the extremist group's bases in Dayr al-Zawr and according to spokesman Bahram Qassemi of the foreign ministry, they were "fatal blows" which served as "just a wake-up warning to those who still can not or have not managed to decently comprehend the realities of the region and their own limits".
Earlier on Monday, Iran's Islamic Revolution Guards Corps (IRGC) announced that the Sunday attack on the "terrorists" in Syria's eastern region of Deir ez-Zor had been coordinated with the Syrian government.
For all the talk this morning about the Iranian ballistic missile strike on an ISIS target in Syria, the real story is that 6 out of the 7 missiles that Iran fired failed to actually hit their intended target.
Both the administration of former President Barack Obama and Trump's have focused exclusively on defeating Islamic State, but with the militants' self-proclaimed caliphate shrinking, USA -backed and Syrian-backed forces appear to be competing for territory.
Despite these efforts, a Syrian SU-22 warplane later arrived on the scene and dropped bombs near the US -backed rebels.
"The Islamic Republic of Iran is standing on the front line, with powerful countries, in terms of missile power", Boroujerdi said following the attack.
The agreement covers four zones in Syria where the rebels are fighting pro-government forces.
US warplanes buzzed the pro-Assad forces in an attempt to scare them away from the rebels, and contacted the Russian military to defuse the situation.
On Monday, Russia warned the United States that it will treat the US-led coalition planes in Syria, west of the Euphrates, as targets.
It marked the first time Tehran has fired into Syria from Iranian territory, using bases in Kermanshah and Kurdistan.
Speaking in Washington, the top US military officer said the two sides were in delicate discussions to lower tensions. "That's why there's no threat of direct confrontation between Russian Federation and American aircraft". "The coalition does not seek to fight the Syrian regime, Russian, or pro-regime forces, but will not hesitate to defend coalition or partner forces from any threat".
Iran's ballistic missile strike targeting the Islamic State group in Syria served both as revenge for attacks on Tehran earlier this month and a warning that Iran could strike Saudi Arabia and US interests in the Mideast, an Iranian general said Monday.
More than 170 "terrorists" including some commanders were killed in the missile strike, their statement said.
The president also pointed to an anti-Iran sanctions bill passed by the USA senate last week, saying the new officials in Washington have made wrong calculations if they think they could pressure Iran with congressional measures.
Iranian legislators claimed the strike was also a sign to the USA that Iran's ballistic missile program will not be deterred by sanctions. The national TV showed footages of missile attacks launched from western Iran.
He added that the missile raid, which took place at a time when "witless" USA senators passed a bill to impose "shameful and anti-JCPOA" sanctions against the IRGC and the Iranian nation, reminded the enemy front that any threat and aggression against Iran's national security will be faced with the reaction of the country's' armed forces backed by the people.
Israel also remains concerned about Iran's missile launches.
The strike came a few days after the US Senate passed a bill on new sanctions against Iran.
The Guard, which answers only to Supreme Leader Ayatollah Ali Khamenei, called the launch "Operation Laylat al-Qadar", referring to the night Muslims believe the Quran was first revealed to the Prophet Muhammad. This month Syrian Kurdish and Arab fighters, supported by USA advisers and air power, began the battle for Raqqa, the militants' self-declared capital.
A number of news outlets describe the attack as an escalation in the Syrian Civil War, but from an Iranian perspective this may not necessarily the case. He rose to be one of the extremist group's leading ideologues.
Another front is shaping up on the ground below, with Assad's forces, which are also battling the Islamic State group, reaching the Iraqi border in the distant east.