The widespread external interest in the candidate - who lives beyond the borders of the sixth himself - became a point of contention for Republicans, who decried that over 95 percent of his donations came from outside Georgia. "We gotta address it or we're going to continue to lose".
The Georgia 6th District race was awash in outside cash, and became the most-expensive House race in US history.
However, Ossoff led in some polls heading into the race, and overall more than $30 million went into what was ultimately a losing effort.
Earlier in the show, the NY mayor said while he didn't vote for Trump he thinks everyone should hope that he will be a "good president". At the end of the day, those individuals are members of the 6th District, citizens of the 6th district as well.
Critics, however, have argued this is precisely the approach that has failed time and time again; it "hasn't been doing well for Democrats for quite some time", wrote policy analyst Ben Spielberg.
Democrats face gerrymandered districts after the last census combined with Trump selecting lawmakers for his administration from districts the GOP should hold. The Republican voters that love Trump don't necessarily love them. This is more than double the 56,830 early ballots cast in the April 18 special election.
"I don't think that very many Republicans will take much comfort on the health care issue even if Handel does win", said veteran Democratic pollster Geoff Garin in advance of Tuesday's result.
Trump, five months into his presidency, has had scant legislative success in enacting his agenda, with Democrats blocking or stalling many of his proposals. "By the end of the campaign, people were exhausted of hearing Pelosi's name over and over".
Democrats are left with the bitter hope of another tighter-than-usual margin, still searching for a contest where anti-Trump energy and flush campaign coffers actually add up to victory. "All the Fake News, all the money spent = 0".
Even as Ossoff lost, Democrats' spirits were somewhat lifted by the unexpectedly strong showing of their nominee in another special House election Tuesday, in SC. She won the election despite Trump, not because of him.
"We have a lot work to do", Handel said. Tax reform. That's the kind of things we've got to get done. Neither was there any sense from him that Trump's party had done well in this democratic election. "And I say that ladies and gentlemen in regards to both sides of the political aisle".
The party has faced trouble recruiting strong candidates and turning dollars spent into electoral wins.
Supporters react as election results for Republican candidate for Georgia's 6th Congressional District seat Karen Handel are shown on a television during an election-nigh.
Rep. Tim Ryan (D-Ohio) said the party is in desperate need of fresh faces in its leadership ranks.
He made the statement while endorsing eight 2018 candidates, and did not mention Pelosi. Former R.N.C. communications director Doug Heye said a victory for Ossoff would heighten existing concerns within the ranks that Trump's historic unpopularity could cost the party its majority in Congress. "Time to stop rehashing 2016 and talk about the future". Instead of praying for dry weather, they might want to take a hard look at some of the factors within their control that are turning voters off in ostensibly competitive races like these.
Later, she went a step further.
"We put a lot of resources, a lot of fight, and close is only good in horseshoes", said Rep. Bill Pascrell, D-N.J.
Nancy Pelosi at the Capitol on May 25.
Democrats tried an inoffensive moderate message in Georgia. "Presidents always have trouble in midterm elections when they've just been elected, and Trump has tremendous trouble with college-educated, suburban voters".
Although CNN hadn't called the race for Handel yet, it was clear the Democrats' candidate had lost.
"The national media got it right: this was a referendum on President Trump". "The Trump agenda is being confirmed".